Journal of Acupuncture and Meridian Studies
Volume 2, Issue 1 , Pages 75-78, March 2009

The Effect of Carum Copticum Extract on Acetylcholine Induced Contraction in Isolated Rat's Ileum

  • Seyed Hassan Hejazian-Y

      Affiliations

    • Herbal Medicine Research Center, School of Medicine, Shahid Sadughi University of Medical Sciences and Health Services, Yazd, Iran
    • ,
  • Mohammad Hossein Dashti-R

      Affiliations

    • Department of Physiology, School of Medicine, Shahid Sadughi University of Medical Sciences and Health Services, Yazd, Iran
    • Corresponding Author InformationCorresponding author. Department of Physiology, Shahid Sadughi School of Medicine, Booali St. Safaeyah, Yazd 8944157963, Iran
    • ,
  • Seyed Majid Mahdavi

      Affiliations

    • Department of Pharmacology, School of Medicine, Shahid Sadughi University of Medical Sciences and Health Services, Yazd, Iran
    • ,
  • Masood Anvar Qureshi

      Affiliations

    • Department of Physiology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan

Received 5 August 2008; accepted 13 January 2009.

Abstract 

Aims

There are many biological investigations for determining an effective cure for the dysfunction of gastrointestinal tracts, using herbal medicine. It has been reported that Carum Copticum is a bactericidal agent and possesses anticholinergic, antihistaminic and b-adrenergic stimulatory effects in some tissues. However, these effects of Carum Copticum on mechanical activities of isolated intestine are not clearly identified yet. The present study has been designed to find out the specific effects of Carum Copticum on mechanical activity of isolated rat's ileum.

Materials and Methods

In this study rat's ileum contraction was recorded through an isolated tissue chamber in an organ bath by using isotonic transducer and oscillographic device. The effect of Carum Copticum extract on acetylcholine induced contraction in isolated rat's ileum was evaluated.

Results

Our findings showed that 1% aqueous extract of Carum Copticum reduces the basal contractile activity of rat's ileum. The extract also reduced acetylcholine induced contraction to 40% of its maximum response. The inhibitory action of Carum Copticum extract on acetylcholine induced contraction was similar but slower than that of atropine sulfate.

Conclusion

The results of this study showed an inhibitory effect of Carum Copticum extract on acetylcholine induced contraction in rat's ileum.

Key Words:  acetylcholine , Carum Copticum , contraction , ileum

 

PII: S2005-2901(09)60019-4

doi:10.1016/S2005-2901(09)60019-4

Journal of Acupuncture and Meridian Studies
Volume 2, Issue 1 , Pages 75-78, March 2009

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