Journal of Acupuncture and Meridian Studies
Volume 1, Issue 2 , Pages 128-138 , December 2008

Effect of Herbal Ephedra sinica and Evodia rutaecarpa on Body Composition and Resting Metabolic Rate: A Randomized, Double-blind Clinical Trial in Korean Premenopausal Women

  • Ho-Jun Kim

      Affiliations

    • Department of Oriental Rehabilitation Medicine, Dongguk University Ilsan Hospital, Korea
    • ,
  • Jung-Mi Park

      Affiliations

    • Department of Oriental Internal Medicine (Cardiovascular and Neurology), East-West Neo Medical Center, KyungHee University, Korea
    • Corresponding Author InformationCorresponding author. Department of Oriental Internal Medicine, East-West Neo Medical Center, KyungHee University, 149 Sang-il, Gangdong, Seoul, Korea
    • ,
  • Jin-Ah Kim

      Affiliations

    • Department of Oriental Internal Medicine (Cardiovascular and Neurology), East-West Neo Medical Center, KyungHee University, Korea
    • ,
  • Byeong-Pyo Ko

      Affiliations

    • Department of Oriental Rehabilitation Medicine, Bundang CHA Hospital, Pochon CHA University, Korea

Received 31 May 2008 ,Accepted 15 October 2008.

References 

  1. Astrup A, Gotzsche PC, van de Werken K, Ranneries C, Toubro S, Raben A, et al. Meta-analysis of resting metabolic rate in formerly obese subjects . Am J Clin Nutr . 1999;69:1117–1122
  2. Heymsfield SB , Allison DB , Vasselli JR , Pietrobelli A , Greenfield D , Nunez C . Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial . JAMA . 1998;280:1596–1600
  3. Boozer CN , Nasser JA , Heymsfield SB , Wang V , Chen G , Solomon JL . An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial . Int J Obes Relat Metab Disord . 2001;25:316–324
  4. Rotblatt M , Ziment I . In: Evidence-based herbal medicine . 1st ed.. Los Angeles, USA: Hanley & Belfus; 2001;p. 127–129 (Korean Version)
  5. Greenway FL , De Jonge L , Blanchard D , Frisard M , Smith SR . Effect of a dietary herbal supplement containing caffeine and ephedra on weight, metabolic rate, and body composition . Obes Res . 2004;12:1152–1157
  6. Kobayashi Y , Nakano Y , Kizaki M , Hoshikuma K , Yokoo Y , Kamiya T . Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist . Planta Med . 2001;67:628–633
  7. Kobayashi Y , Nakano Y , Hoshikuma K , Yokoo Y , Kamiya T . The bronchoconstrictive action of evodiamine, an indo-loquinazoline alkaloid isolated from the fruits of Evodia rutaecarpa, on guinea-pig isolated bronchus: possible involvement on vanilloid receptors . Planta Med . 2000;66:526–530
  8. Nieman DC , Trone GA , Austin MD . A new handheld device for measuring resting metabolic rate and oxygen consumption . J Am Diet Assoc . 2003;103:588–592
  9. Ravussin E . Low resting metabolic rate as a risk factor for weight gain: role of the sympathetic nervous system . Int J Obes Relat Metab Disord . 1995;19(Suppl 7):S8–S9
  10. Ko E, Rho S, Lee EJ, Seo YH, Cho C, Lee Y, et al. Traditional Korean medicine (SCRT) modulate Th1/Th2 specific cytokine production in mice CD4+ T cell . J Ethnopharmacol . 2004;92:121–128
  11. Zachwieja JJ . Exercise as treatment for obesity . Endocrinol Metab Clin North Am . 1996;25:965–988
  12. Bent S , Tiedt TN , Odden MC , Shlipak MG . The relative safety of ephedra compared with other herbal products . Ann Intern Med . 2003;138:468–471
  13. Peirce A . In: The American Pharmaceutical Association Practical Guide to Natural Medicines . 1st ed.. New York, USA: William Morrow; 1999;p. 246–248
  14. Malchow-Moller A , Larsen S , Hey H , Stokholm KH , Juhl E , Quaade F . Ephedrine as an anorectic: the story of the ‘Elsinore pill’ . Int J Obes . 1981;5:183–187
  15. Astrup A, Buemann B, Christensen NJ, Toubro S, Thorbek G, Victor OJ, et al. The effect of ephedrine/caffeine mixture on energy expenditure and body composition in obese women . Metabolism . 1992;41:686–688
  16. Hirsch J , Mackintosh RM , Aronne LJ . The effects of drugs used to treat obesity on the autonomic nervous system . Obes Res . 2000;8:227–233
  17. Alger S, Larson K, Boyce VL, Seagle H, Fontvieille AM, Ferraro RT, et al. Effect of phenylpropanolamine on energy expenditure and weight loss in overweight women . Am J Clin Nutr . 1993;57:120–126
  18. Seagle HM , Bessesen DH , Hill JO . Effects of sibutramine on resting metabolic rate and weight loss in overweight women . Obes Res . 1998;6:115–121
  19. Vukovich MD , Schoorman R , Heilman C , Jacob P , Benowitz NL . Caffeine-herbal ephedra combination increases resting energy expenditure, heart rate and blood pressure . Clin Exp Pharmacol Physiol . 2005;32:47–53
  20. Shoji N , Umeyama A , Takemoto T , Kajiwara A , Ohizumi Y . Isolation of evodiamine, a powerful cardiotonic principle, from Evodia rutaecarpa Bentham(Rutaeceae) . J Pharm Sci . 1986;5:612–613
  21. Shekelle PG, Hardy ML, Morton SC, Maglione M, Mojica WA, Suttorp MJ, et al. Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis . JAMA . 2003;289:1537–1545
  22. Greenway FL . The safety and efficacy of pharmaceutical and herbal caffeine and ephedrine use as a weight loss agent . Obes Rev . 2001;2:199–211
  23. White LM , Gardner SF , Gurley BJ , Marx MA , Wang PL , Estes M . Pharmacokinetics and cardiovascular effects of ma-huang (Ephedra sinica) in normotensive adults . J Clin Pharmacol . 1997;37:116–122
  24. Boozer CN, Daly PA, Homel P, Solomon JL, Blanchard D, Nasser JA, et al. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial . Int J Obes Relat Metab Disord . 2002;26:593–604

PII: S2005-2901(09)60033-9

doi: 10.1016/S2005-2901(09)60033-9

Journal of Acupuncture and Meridian Studies
Volume 1, Issue 2 , Pages 128-138 , December 2008

Article Tools

* Image Usage & Resolution