Journal of Acupuncture and Meridian Studies
Volume 2, Issue 3 , Pages 210-217 , September 2009

Apoptosis Induction of Human Lung Carcinoma Cells by Chan Su (Venenum Bufonis) Through Activation of Caspases

  • Hye Ri Yun

      Affiliations

    • Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan, Republic of Korea
    • These authors contributed equally.
  • ,
  • Hwa Seung Yoo

      Affiliations

    • Department of Biomaterial Control (BK21 program), Graduate School and Blue-Bio Industry Regional Innovation Center, Dongeui University, Busan, Republic of Korea
    • These authors contributed equally.
  • ,
  • Dong Yeok Shin

      Affiliations

    • Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan, Republic of Korea
  • ,
  • Su Hyun Hong

      Affiliations

    • Department of Internal Medicine, College of Oriental Medicine, Dongeui University, Busan, Republic of Korea
  • ,
  • Jong-Hwan Kim

      Affiliations

    • Department of East-West Cancer Center, College of Oriental Medicine, Daejeon University, Daejeon, Republic of Korea
  • ,
  • Chong Kwan Cho

      Affiliations

    • Department of Biomaterial Control (BK21 program), Graduate School and Blue-Bio Industry Regional Innovation Center, Dongeui University, Busan, Republic of Korea
  • ,
  • Yung Hyun Choi

      Affiliations

    • Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan, Republic of Korea
    • Department of Biomaterial Control (BK21 program), Graduate School and Blue-Bio Industry Regional Innovation Center, Dongeui University, Busan, Republic of Korea
    • Corresponding Author InformationCorresponding author. Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan 614-052, Republic of Korea

Received 16 June 2009 ,Accepted 14 July 2009.

References 

  1. Makin G , Dive C . Apoptosis and cancer chemotherapy . Trends Cell Biol . 2001;11:22–26
  2. Ghobrial IM , Witzig TE , Adjei AA . Targeting apoptosis pathways in cancer therapy . CA Cancer J Clin . 2005;55:178–194
  3. Earnshaw WC , Martins LM , Kaufmann SH . Mammalian caspases: structure, activation, substrates, and functions during apoptosis . Annu Rev Biochem . 1999;6:383–424
  4. Adams JM , Cory S . Life-or-death decisions by the Bcl-2 protein family . Trends Biochem Sci . 2001;26:61–66
  5. Stennicke HR , Salvesen GS . Properties of the caspases . Biochim Biophys Acta . 1998;1387:17–31
  6. Hengartner MO . The biochemistry of apoptosis . Nature . 2000;407:770–776
  7. Nagata S , Golstein P . The Fas death factor . Science . 1996;267:1449–1456
  8. Jiang C , Yang YF , Cheng SH . Fas ligand gene therapy for vascular intimal hyperplasia . Curr Gene Ther . 2004;4:33–39
  9. Jeong SY , Seol DW . The role of mitochondria in apoptosis . BMB Rep . 2008;41:11–22
  10. Clarke BT . The natural history of amphibian skin secretions, their normal functioning and potential medical applications . Biol Rev . 1997;72:365–379
  11. Steyn PS , Van Heerden FR . Bufadienolides of plants and animal origin . Nat Prod Rep . 1998;15:397–413
  12. Bhuiyan MB , Fant ME , Dasgupta A . Study on mechanism of action of Chinese medicine Chan Su: dose-dependent biphasic production of nitric oxide in trophoblastic BeWo cells . Clin Chim Acta . 2003;330:179–184
  13. Nogawa T , Kamano Y , Yamashita A , Pettit GR . Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su . J Nat Prod . 2001;64:1148–1152
  14. Wang J , Jin Y , Xu Z , Zheng Z , Wan S . Involvement of caspase-3 activity and survivin downregulation in cinobufocini-induced apoptosis in A549 cells . Exp Biol Med (Maywood) . 2009;234:566–572
  15. Li D , Qu X , Hou K , Zhang Y , Dong Q , Teng Y , et al.   PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells . Anticancer Drugs . 2009;20:59–64
  16. Giri B , Gomes A , Debnath A , Saha A , Biswas AK , Dasgupta SC , et al.   Antiproliferative, cytotoxic and apoptogenic activity of Indian toad (Bufo melanostictus, Schneider) skin extract on U937 and K562 cells . Toxicon . 2006;48:388–400
  17. Huang C , Chen A , Guo M , Yu J . Membrane dielectric responses of bufalin-induced apoptosis in HL-60 cells detected by an electrorotation chip . Biotechnol Lett . 2007;29:1307–1313
  18. Kawazoe N , Watabe M , Masuda Y , Nakajo S , Nakaya K . Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells . Oncogene . 1999;18:413–2421
  19. Watabe M , Kawazoe N , Masuda Y , Nakajo S , Nakaya K . Bcl-2 protein inhibits bufalin-induced apoptosis through inhibition of mitogen-activated protein kinase activation in human leukemia U937 cells . Cancer Res . 1997;57:3097–3100
  20. Masuda Y , Kawazoe N , Nakajo S , Yoshida T , Kuroiwa Y , Nakaya K . Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells . Leuk Res . 1995;19:549–556
  21. Jing Y , Ohizumi H , Kawazoe N , Hashimoto S , Masuda Y , Nakajo S , et al.   Selective inhibitory effect of bufalin on growth of human tumor cells in vitro: association with the induction of apoptosis in leukemia HL-60 cells . Jpn J Cancer Res . 1994;85:645–651
  22. Ko WS , Park TY , Park C , Kim YH , Yoon HJ , Lee SY , et al.   Induction of apoptosis by Chan Su, a traditional Chinese medicine, in human bladder carcinoma T24 cells . Oncol Rep . 2005;14:475–480
  23. Dash R , Acharya C , Bindu PC , Kundu SC . Antioxidant potential of silk protein sericin against hydrogen peroxide-induced oxidative stress in skin fibroblasts . BMB Rep . 2008;41:236–241
  24. Lazebnik YA , Kaufmann SH , Desnoyers S , Poirier GG , Earnshaw WC . Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE . Nature . 1994;371:346–347
  25. Fukuda K . Apoptosis-associated cleavage of β-catenin in human colon cancer and rat hepatoma cells . Int J Biochem Cell Biol . 1999;31:519–529
  26. Han SI , Kim YS , Kim TH . Role of apoptotic and necrotic cell death under physiologic conditions . BMB Rep . 2008;41:1–10

PII: S2005-2901(09)60057-1

doi: 10.1016/S2005-2901(09)60057-1

Journal of Acupuncture and Meridian Studies
Volume 2, Issue 3 , Pages 210-217 , September 2009