Journal of Acupuncture and Meridian Studies
Volume 2, Issue 4 , Pages 280-287 , December 2009

Anti-inflammatory and Analgesic Effects of Elephantopus tomentosus Ethanolic Extract

  • Mun Fei Yam

      Affiliations

    • School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Pulau Pinang, Malaysia
    • Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia
    • Corresponding Author InformationCorresponding author. Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia
  • ,
  • Lee Fung Ang

      Affiliations

    • School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Pulau Pinang, Malaysia
  • ,
  • Omar Ziad Ameer

      Affiliations

    • School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Pulau Pinang, Malaysia
  • ,
  • Ibrahim Muhammad Salman

      Affiliations

    • School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Pulau Pinang, Malaysia
  • ,
  • Hesham Abdul Aziz

      Affiliations

    • School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Pulau Pinang, Malaysia
  • ,
  • Mohd. Zaini Asmawi

      Affiliations

    • School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Pulau Pinang, Malaysia

Received 29 April 2009 ,Accepted 29 September 2009.

References 

  1. Sosa S , Balick MJ , Arvigo R , Esposito RG , Pizza C , Altinier G , et al.   Screening of the topical anti-inflammatory activity of some Central American plants . J Ethnopharmacol . 2002;81:211–215
  2. Yam MF , Asmawi MZ , Basir R . An investigation of the antiinflammatory and analgesic effects of Orthosiphon stamineus leaf extract . J Med Food . 2008;11:362–368
  3. Andrade SF , Lemos M , Comunello E , Noldin VF , Filho VC , Niero R . Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models . J Ethnopharmacol . 2007;113:252–257
  4. Gooch K , Culleton BF , Manns BJ , Zhang J , Alfonso H , Tonelli M , et al.   NSAID use and progression of chronic kidney disease . Am J Med . 2007;120: 280e1–280e7
  5. Jaganath IB , Ng LT . In: Herbs the green pharmacy of Malaysia . Kuala Lumpur: Vinpress; 2000;p. 76–77
  6. Yam MF , Basir R , Asmawi MZ , Rosdiah  , Ahmad M , Akowuah GA . Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract . Pharm Biol . 2008;46:199–206
  7. Winter CA , Risley EA , Nus GV . Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drug . Proc Soc Exp Biol Med . 1962;111:544–547
  8. Whittle BA . The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics . Br J Pharmacol Chemother . 1964;22:246–253
  9. Winter CA , Flataker L . Nociceptive thresholds as affected by parenteral administration of irritants and of various antinociceptive drugs . J Pharmacol Exp Ther . 1965;148:373–379
  10. Iwalewa EO , Iwalewa OJ , Adeboye JO . Analgesic, antipyretic, anti-inflammatory effects of methanol, chloroform and ether extracts of Vernonia cinerea less leaf . J Ethnopharmacol . 2003;86:229–234
  11. Koster R , Anderson M , DeBeer EJ . Acetic acid for analgesic screening . Fed Proc . 1959;18:412
  12. Harborne JB . In: Phytochemical methods: A guide to modern techniques of plant Analysis . London: Chapman & Hall; 1973;p. 279
  13. Awe IS , Sodipo OA . Purification of saponins of root of Bhlighiasapida Koenig-Holl . Nig J Biochem Mol Biol . 2001;16:s2014
  14. Sofowora A . In: Medicinal Plants and Traditional Medicine in Africa . 2nd ed.. Nigeria: Spectrum Books Ltd; 1993;p. 134–156
  15. Odebiyi A , Sofowora AE . Phytochemical screening of Nigerian medicinal plants (III) . Lloydia . 1978;41:234–246
  16. Owoyele OV , Adebukola OM , Funmilayo AA , Soladoye OA . Anti-inflammatory activities of ethanolic extract of Carica papaya leaves . Inflammopharm . 2008;16:168–173
  17. Trease GE , Evans WC . A textbook of Pharmacognosy . 13th ed.. London: Bailliere-Tyndall Ltd.; 1989;
  18. Brito ARMS , Antonio MA . Oral anti-inflammatory and antiulcerogenic activities of a hydroalcoholic extract and partitioned fractions of Turnera ulmifolia (Turneraceae) . J Ethnopharmacol . 1998;61:215–228
  19. Di Rosa M . Review. Biological properties of carrageenan . J Pharm Pharmacol . 1972;24:89–102
  20. Di Rosa M , Giroud JP , Willoughby DA . Studies of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine . J Pathol . 1971;104:15–29
  21. Crunkhon P , Meacock SER . Mediators of the inflammation induced in the rat paw by carrageenan . Brit J Pharmacol . 1971;42:392–402
  22. Mossa JS , Rafatullah S , Galai AM , Al-Yahya MA . Pharmacological studies of Rhus retinorrhaea . Int J Pharmacog . 1995;33:242–246
  23. Kang HS , Lee JY , Kim CJ . Anti-inflammatory activity of arctigenin from Forsythiae Fructus . J Ethnopharm . 2008;116:305–311
  24. Prado WA , Tonussi CR , Rego EM , Corrado AP . Antinociception induced by intraperitoneal injection of gentamicin in rats and mice . Pain . 1990;4:365–371
  25. Gupta M , Mazumder UK , Kumar RS , Gomathi P , Rajeshwar Y , Kakoti BB , et al.   Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models . J Ethnopharmacol . 2005;98:267–273
  26. Ferreira SH , Vane SR . New aspects on the mode of action of non-steroid anti-inflammatory drugs . Ann Rev Pharmacol . 1974;14:57–73
  27. Perianayagam JB , Sharma SK , Joseph A , Christina AJM . Evaluation of anti-pyretic and analgesic activity of Emblica officinalis Gaertn . J Ethnopharmacol . 2004;95:83–85
  28. Ferreira SH . Prostaglandins . In: Chemical messengers of the inflammatory process . Amsterdam: Elsevier/North-Holland Biomedical Press; 1979;p. 113–151
  29. Bars D , Gozariu M , Cadden SW . Animals models of nociception . Pharmacol Rev . 2001;53:597–652
  30. Koo HJ , Lim KH , Jung HJ , Park EH . Anti-inflammatory evaluation of gardenia extract, geniposide and genipin . J Ethnopharmacol . 2006;103:496–500
  31. Hokanson GC . Acetic acid for analgesic screening . J Nat Prod . 1978;41:497–498
  32. Duarte JDG , Nakamura M , Ferreira SH . Participation of the sympathetic system in acetic acid induced writhing in mice . Braz J Med Biol Res . 1988;21:341–343
  33. Garcia-Leme J , Nakamura L , Leite MP , Rochae Silva M . Pharmacological analysis of the acute inflammation process induced in rat's paw by local injection of carrageenan and heating . Brit J Pharmacol . 1973;64:91–98
  34. Hosseinzadeh H , Younesi HM . Antinociceptive and antiinflammatory effects of Crocus sativus L. stigma and petal extracts in mice . BMC Pharmacol . 2002;2:7–16
  35. Wang JR , Zhou H , Jiang ZH , Wong YF , Liu L . In vivo antiinflammatory and analgesic activities of a purified saponin fraction derived from the root of Ilex pubescens . Biol Pharm Bull . 2008;31:643–650
  36. Thirugnanasambantham P , Viswanathan S , Ramaswamy S , Krishnamurty V , Mythirayee C , Kameswaran L . Analgesic activity of certain flavone derivatives: a structure-activity study . Clinical Exp Pharm Physiol . 2007;20:59–63
  37. Viana GSB , Bandeira MAM , Moura LC , Souza-Filho MVP , Matos FJA , Ribeiro RA . Analgesic and antiinflammatory effects of the tannin fraction from Myracrodruon urundeuva Fr. All . Phytother Res . 1998;11:118–122
  38. Loomis TA , Hayes AW . Loomis's Essentials of Toxicology . CA: Academic Press; 1996;

PII: S2005-2901(09)60069-8

doi: 10.1016/S2005-2901(09)60069-8

Journal of Acupuncture and Meridian Studies
Volume 2, Issue 4 , Pages 280-287 , December 2009