Evaluation of the Analgesic Effect of Dextromethorphan and its Interaction With Nitric Oxide on Sciatic Nerve Ligated Rats

Latency response of sham-operated A group in comparison with sciatic nerve ligated B group (n = 6, data shown as mean ± SEM). ^*p < 0.05.

Latency response of dextromethorphan (Dex) treated group in comparison with saline treated group (n = 6, data shown as mean ± SEM). ^*p < 0.05. NS = normal saline treated group.

Latency response of the L-nitro-arginine methyl ester (L-NAME) treated group in comparison with the saline treated group (n = 6, mean ± SEM). ^*p < 0.05. NS = normal saline treated group.

Effect of L-nitro-arginine methyl ester (L-NAME) on the latency response of dextromethorphan (Dex) in comparison with the Dex-only treated group (n= 6, mean ± SEM). ^*p < 0.05.