Effects of Teucrium polium on Insulin Resistance in Nonalcoholic Steatohepatitis

Histological evaluation of rat livers. (A) Group A (normal diet) showing normal liver histology (100×). (B) Group B (MCD diet) showing macro and microsteatosis, ballooning degeneration and lobular inflammation (400×). (C) Group C (MCD diet + Teucrium polium crude extract) showing marked reduction in steatosis, ballooning degeneration and lobular inflammation (100×). (D) Group D (MCD diet + T. polium ethyl acetate fraction) showing some degrees of steatosis with marked reduction in ballooning degeneration and lobular inflammation (100×). MCD=methionine/choline deficient.

Effect of Teucrium polium on (A) serum lipoprotein profile and (B) hepatic enzymes. Group A (normal diet), group B (MCD diet), group C (MCD diet + T. polium crude extract) and group D (MCD diet + T. polium ethyl acetate fraction). Results shown as mean±SD (n=5) of triplicate measurements of each sample. *p < 0.05 compared to group A. ^† p < 0.05 compared to group B. MCD=methionine/choline deficient; VLDL=very low density lipoproteins; HDL=high density lipoproteins; LDL=low density lipoproteins; ALP=alkaline phosphatase; ALT=alanine aminotransferase; AST=aspartate aminotransferase; GGT=γ-glutamyl transferase.

Effect of Teucrium polium extract on liver oxidative status. Group A (normal diet), group B (MCD diet), group C (MCD diet + T. polium crude extract) and group D (MCD diet + T. polium ethylacetate fraction). Results shown as mean±SD (n=5) of triplicate measurements of each sample. *p < 0.05 as compared to group A. ^†p < 0.05 as compared to group B. MCD=methionine/choline deficient; SOD=superoxide dismutase; GPx=glutathione peroxidase; GR=glutathione reductase; MDA=malondialdehyde; GSH=reduced glutathione.

Effect of Teucrium polium extract on insulin resistance status. Insulin resistance is presented using the homeostasis model assessment (HOMA) of insulin resistance index. Group A (normal diet), group B (MCD diet), group C (MCD diet + T. polium crude extract) and group D (MCD diet + T. polium ethyl acetate fraction). Results shown as mean±SD (n=5) of triplicate measurements of each sample. *p < 0.05 as compared to group A. ^†p < 0.05 as compared to group B. MCD=methionine/choline deficient.