Journal of Acupuncture and Meridian Studies
Volume 3, Issue 2 , Pages 116-118 , June 2010

5α-Reductase Inhibitory Components as Antiandrogens From Herbal Medicine

  • Chul-Ho Cho

      Affiliations

    • Department of Medical Management, College of Health and Therapy, Daegu Haany University, Gyeongsangbuk-do, Korea
    • ,
  • Jong-Sup Bae

      Affiliations

    • Department of Herbal Pharmaceutical Engineering, College of Herbal Bio-industry, Daegu Haany University, Gyeongsangbuk-do, Korea
    • ,
  • Yong-Ung Kim

      Affiliations

    • Department of Herbal Pharmaceutical Engineering, College of Herbal Bio-industry, Daegu Haany University, Gyeongsangbuk-do, Korea
    • Corresponding Author InformationCorresponding author. Department of Herbal Pharmaceutical Engineering, College of Herbal Bio-industry, Daegu Haany University, 290, Yugok-dong, Gyeongsan-si, Gyeongsangbuk-do 712-715, Korea

Received 10 February 2010 ,Accepted 12 April 2010.

References 

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  2. Komoda Y . Isolation of flavonoids from Populus nigra as D4-3-ketosteroid (5a) reductase inhibitors . Chem Pharm Bull . 1989;37:3128–3130
  3. Lesuisse D , Berjonneau J , Ciot C , Devaux P , Doucet B , Gourvest JF , et al.   Determination of oenothein B as the active 5-a-reductase-inhibiting principle of the folk medicine Epilobium parviflorum . J Nat Prod . 1996;59:490–492
  4. Shimizu K , Fukuda M , Kondo R , Sakai K . The 5a-reductase inhibitory components from heartwood of Artocarpus incisus: structure-activity investigations . Planta Med . 2000;66:16–19
  5. Shimizu K , Kondo R , Sakai K , Shoyama Y , Sato H , Ueno T . Steroid 5a-reductase inhibitory activity and hair regrowth effects of an extract from Boehmeria nipononivea . Biosci Biotechnol Biochem . 2000;64:875–877
  6. Ishiguro K , Oku H , Kato T . Testosterone 5a-reductase inhibitor bisnaphthoquinone derivative from Impatiens balsamina . Phytother Res . 2000;14:54–56
  7. Matsuda H , Yamazaki M , Matsuo K , Asanuma Y , Kubo M . Anti-androgenic activity of Myricae Cortex-Isolation of active constituents from bark of Myrica rubra . Biol Pharm Bull . 2001;24:259–263
  8. Seo EK , Kim KH , Kim MK , Cho MH , Choi E , et al.   Inhibitors of 5a-reductase type I in LNCaP cells from the roots of Angelica koreana . Planta Med . 2002;68:162–163
  9. Kim Y , Son HK , Song HK , Ahn MJ , Lee SS , Lee SK . Inhibition of 5a-reductase activity by diarylheptanoids from Alpinia officinarum . Planta Med . 2003;69:72–74
  10. Park WS , Son ED , Nam GW , Kim SH , Noh MS , Lee BG , et al.   Torilin from Torilis japonica, as a new inhibitor of testosterone 5a-reductase . Planta Med . 2003;69:459–461
  11. Liu J , Kurashiki K , Shimizu K , Kondo R . 5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum . Biol Pharm Bull . 2006;29:392–395
  12. Kim Y , Kim CY , Son HK , Song HK , Han J , Lee SS , et al.   Testosterone 5a-reductase inhibitors, menaquinone 7 produced by a Bacillus and phenazine methosulfate . Biol Pharm Bull . 1999;22:1396–1399
  13. Li-Shuang LV , Gu X , Ho CT . Stilbene glycosides from the roots of Polygonum multiflorum Thunb and their antioxidant activities . J Food Lipids . 2006;13:131–144
  14. Hiipakka RA , Zhang HZ , Dai W , Dai Q , Liao S . Structure-activity relationships for inhibition of human 5a-reductases by polyphenols . Biochem Pharmacol . 2002;63:1165–1176

PII: S2005-2901(10)60021-0

doi: 10.1016/S2005-2901(10)60021-0

Journal of Acupuncture and Meridian Studies
Volume 3, Issue 2 , Pages 116-118 , June 2010

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